This metabolite has a PDE selectivity profile similar to sildenafil and an in vitro potency for PDE5 close to fifty% from the dad or mum drug. Plasma concentrations of the metabolite are about forty% of those witnessed for sildenafil, so that the metabolite accounts for about twenty% of sildenafil's pharmacologic results.

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Sildenafil improves the influence of NO by inhibiting phosphodiesterase form five (PDE5), and that is chargeable for degradation of cGMP during the corpus cavernosum. Sildenafil has no immediate relaxant impact on isolated human corpus cavernosum.

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